Speaker of the Research Department of Neuroscience
Department of Neurophysiology
Faculty of Medicine
Ruhr University Bochum
Universitätsstr. 150
44801 Bochum
Room:
MA 4/150
Phone:
+49 (0)234 32-22042
Email:
denise.manahan-vaughan@ruhr-uni-bochum.de
We focus on the characterisation of hippocampal synaptic plasticity as a learning mechanism. Two types of synaptic plasticity are primarily investigated: long-term potentiation (LTP) and long-term depression (LTD). We also study metaplasticity (as a higher order modulator of synaptic plasticity).
We have a multidisciplinary approach which incorporates in vivo electrophysiology in freely moving rodents with in vitro electrophysiology using the hippocampal slice preparation, as well as behavioral analysis of learning, wide-field calcium imaging functional magnet resonance imaging fluorescence in situ hybridisation, immunohistochemical, biochemical and molecular biological analysis. We are interested in both the physiology and pathology of learning and memory / synaptic plasticity.
On a physiological level we examine how synaptic plasticity, place cells and neuronal oscillations contribute to learning and how learning drives synaptic plasticity in health and disease. Here in vivo electrophysiology, fMRI and EEG analysis is combined with behavioral learning models and animal models of brain disorders.
Stacho, M., & Manahan-Vaughan, D. (2022). Mechanistic flexibility of the retrosplenial cortex enables its contribution to spatial cognition. Trends in Neurosciences, 45(4), 284–296. https://doi.org/10.1016/j.tins.2022.01.007
Strauch, C., Hoang, T.‑H., Angenstein, F., & Manahan-Vaughan, D. (2022). Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination. Cerebral Cortex (New York, N.Y. : 1991), 32(4), 689–708. https://doi.org/10.1093/cercor/bhab226
Hoang, T.‑H., Böge, J., & Manahan-Vaughan, D. (2021). Hippocampal subfield-specific Homer1a expression is triggered by learning-facilitated long-term potentiation and long-term depression at medial perforant path synapses. Hippocampus, 31(8), 897–915. https://doi.org/10.1002/hipo.23333
Beckmann, D., Feldmann, M., Shchyglo, O., & Manahan-Vaughan, D. (2020). Hippocampal Synaptic Plasticity, Spatial Memory, and Neurotransmitter Receptor Expression Are Profoundly Altered by Gradual Loss of Hearing Ability. Cerebral Cortex (New York, N.Y. : 1991), 30(8), 4581–4596. https://doi.org/10.1093/cercor/bhaa061
Hauser, M. F. A., Heba, S., Schmidt-Wilcke, T., Tegenthoff, M., & Manahan-Vaughan, D. (2020). Cerebellar-hippocampal processing in passive perception of visuospatial change: An ego- and allocentric axis? Human Brain Mapping, 41(5), 1153–1166. https://doi.org/10.1002/hbm.24865
Poe, G. R., Foote, S., Eschenko, O., Johansen, J. P., Bouret, S., Aston-Jones, G., Harley, C. W., Manahan-Vaughan, D., Weinshenker, D., Valentino, R., Berridge, C., Chandler, D. J., Waterhouse, B., & Sara, S. J. (2020). Locus coeruleus: A new look at the blue spot. Nature Reviews. Neuroscience, 21(11), 644–659. https://doi.org/10.1038/s41583-020-0360-9
Hauser, M. F. A. , Wiescholleck, V., Colitti-Klausnitzer, J., Bellebaum, C., & Manahan-Vaughan, D. (2019). Event-related potentials evoked by passive visuospatial perception in rats and humans reveal common denominators in information processing. Brain Structure & Function, 224(4), 1583–1597. https://doi.org/10.1007/s00429-019-01854-4
Goh, J. J., & Manahan-Vaughan, D. (2013). Spatial object recognition enables endogenous LTD that curtails LTP in the mouse hippocampus. Cerebral Cortex (New York, N.Y. : 1991), 23(5), 1118–1125. https://doi.org/10.1093/cercor/bhs089
Lemon, N., & Manahan-Vaughan, D. (2012). Dopamine D1/D5 receptors contribute to de novo hippocampal LTD mediated by novel spatial exploration or locus coeruleus activity. Cerebral Cortex (New York, N.Y. : 1991), 22(9), 2131–2138. https://doi.org/10.1093/cercor/bhr297
Kemp, A., & Manahan-Vaughan, D. (2008). The hippocampal CA1 region and dentate gyrus differentiate between environmental and spatial feature encoding through long-term depression. Cerebral Cortex (New York, N.Y. : 1991), 18(4), 968–977. https://doi.org/10.1093/cercor/bhm136
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