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Prof. Dr. Stefan Herlitze

Department of Zoology and Neurobiology
Faculty for Biology and Biotechnology
Ruhr University Bochum
Universitätsstr. 150
44801 Bochum

Room: ND 7/0031
Phone: +49 (0)234 32-25607
Email: stefan.herlitze@ruhr-uni-bochum.de


Homepage
orcid.org/0000-0003-1785-0450
Prof. Dr. Stefan Herlitze
Prof. Dr. Stefan Herlitze
Research Interests

In the last years the Department of Zoology and Neurobiology has developed optogenetic tools to control G protein coupled receptor (GPCR) signaling pathways (Li et al., 2005). We are focusing on light activated GPCRs involved in modulating emotional behavior. We demonstrated that the loss of serotonergic signaling within the mouse brain alters the emotional phenotype (Liu et al., 2010) and that the autoregulation of serotonergic neurons, which is involved in regulating 5HT network activity, can be controlled by light activated chimeric vertebrate rhodopsins coupling to the 5-HT1A signaling pathways in hind/midbrain regions of the mouse brain (Oh et al., 2010). Now, we would like to combine cutting edge imaging techniques, i.e. 2 Photon-FLIM and TIRF microscopy, with optogenetic techniques to control and visualize GPCRs coupling to the 5HT signaling pathways in vitro and in vivo. Our goal is to understand how 5HT pathways modulate anxiety states and how these pathways alter the underlying neuronal structure when anxiety can’t be forgotten and manifested in diseases such as depression.